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murine pdac cancer cells  (Jackson Laboratory)

 
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    Jackson Laboratory murine pdac cancer cells
    ( A ) Diagram of experimental models used to test the effect of tumor tissue of origin on TIF metabolite levels. Principal component analysis ( B ) and hierarchical clustering ( C ) of <t>PDAC</t> subcutaneous allograft TIF <t>and</t> <t>LUAD</t> subcutaneous allograft TIF samples based on LC/MS measurements of 104 metabolite concentrations. ( D ) Volcano plot depicting the log 2 fold change in metabolite concentration between PDAC and LUAD TIF for metabolites measured using stable isotope dilution. A fold change of 1.5 and raw p-value of 0.01 assuming unequal variance were used to select significantly altered metabolites indicated in pink. For all panels, n = 5 for PDAC subcutaneous allograft TIF samples and n = 10 for LUAD subcutaneous allograft TIF samples. 10.7554/eLife.44235.034 Figure 5—source data 1. Concentrations of 104 metabolites determined by both external standard calibration and stable isotope dilution in all subcutaneous PDAC and LUAD TIF samples in .
    Murine Pdac Cancer Cells, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/murine+pdac+cancer+cells/murine+pdac+cells/pmc06510537-213-23-17
    Average 90 stars, based on 1 article reviews
    murine pdac cancer cells - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability"

    Article Title: Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

    Journal: eLife

    doi: 10.7554/eLife.44235

    ( A ) Diagram of experimental models used to test the effect of tumor tissue of origin on TIF metabolite levels. Principal component analysis ( B ) and hierarchical clustering ( C ) of PDAC subcutaneous allograft TIF and LUAD subcutaneous allograft TIF samples based on LC/MS measurements of 104 metabolite concentrations. ( D ) Volcano plot depicting the log 2 fold change in metabolite concentration between PDAC and LUAD TIF for metabolites measured using stable isotope dilution. A fold change of 1.5 and raw p-value of 0.01 assuming unequal variance were used to select significantly altered metabolites indicated in pink. For all panels, n = 5 for PDAC subcutaneous allograft TIF samples and n = 10 for LUAD subcutaneous allograft TIF samples. 10.7554/eLife.44235.034 Figure 5—source data 1. Concentrations of 104 metabolites determined by both external standard calibration and stable isotope dilution in all subcutaneous PDAC and LUAD TIF samples in .
    Figure Legend Snippet: ( A ) Diagram of experimental models used to test the effect of tumor tissue of origin on TIF metabolite levels. Principal component analysis ( B ) and hierarchical clustering ( C ) of PDAC subcutaneous allograft TIF and LUAD subcutaneous allograft TIF samples based on LC/MS measurements of 104 metabolite concentrations. ( D ) Volcano plot depicting the log 2 fold change in metabolite concentration between PDAC and LUAD TIF for metabolites measured using stable isotope dilution. A fold change of 1.5 and raw p-value of 0.01 assuming unequal variance were used to select significantly altered metabolites indicated in pink. For all panels, n = 5 for PDAC subcutaneous allograft TIF samples and n = 10 for LUAD subcutaneous allograft TIF samples. 10.7554/eLife.44235.034 Figure 5—source data 1. Concentrations of 104 metabolites determined by both external standard calibration and stable isotope dilution in all subcutaneous PDAC and LUAD TIF samples in .

    Techniques Used: Liquid Chromatography with Mass Spectroscopy, Concentration Assay, Isotope Dilution

    ( A ) Diagram of experimental models used to test the effect of tumor tissue of origin on TIF metabolite levels. Principal component analysis ( B ) and hierarchical clustering ( C ) of PDAC subcutaneous allograft TIF and LUAD subcutaneous allograft TIF samples based on LC/MS measurements of 67 metabolites quantified using isotope-labeled internal standards. For all panels, n = 5 for PDAC subcutaneous allograft TIF samples and n = 10 for LUAD subcutaneous allograft TIF samples. 10.7554/eLife.44235.035 Figure 5—figure supplement 1—source data 1. Concentrations of 66 metabolites determined by only stable isotope dilution in all subcutaneous PDAC and LUAD TIF samples in .
    Figure Legend Snippet: ( A ) Diagram of experimental models used to test the effect of tumor tissue of origin on TIF metabolite levels. Principal component analysis ( B ) and hierarchical clustering ( C ) of PDAC subcutaneous allograft TIF and LUAD subcutaneous allograft TIF samples based on LC/MS measurements of 67 metabolites quantified using isotope-labeled internal standards. For all panels, n = 5 for PDAC subcutaneous allograft TIF samples and n = 10 for LUAD subcutaneous allograft TIF samples. 10.7554/eLife.44235.035 Figure 5—figure supplement 1—source data 1. Concentrations of 66 metabolites determined by only stable isotope dilution in all subcutaneous PDAC and LUAD TIF samples in .

    Techniques Used: Liquid Chromatography with Mass Spectroscopy, Labeling, Isotope Dilution

    Related Articles

    Injection:

    Article Title: Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
    Article Snippet: .. For subcutaneous xenograft studies, 12 week old C57BL/6J animals purchased from Jackson Laboratories (IMSR Cat# JAX:000664, RRID: IMSR_JAX:000664 ) were injected with 100,000 murine PDAC or LUAD cancer cells (suspended in a volume of 100 μL of Matrigel (Corning, 354234) brought to 10 mg/ml with RPMI-1640 (Corning, 50–020-PC) into the subcutaneous space on the flank of the mice. ..



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    murine pdac cancer cells  (Jackson Laboratory)
    90
    Jackson Laboratory murine pdac cancer cells
    ( A ) Diagram of experimental models used to test the effect of tumor tissue of origin on TIF metabolite levels. Principal component analysis ( B ) and hierarchical clustering ( C ) of <t>PDAC</t> subcutaneous allograft TIF <t>and</t> <t>LUAD</t> subcutaneous allograft TIF samples based on LC/MS measurements of 104 metabolite concentrations. ( D ) Volcano plot depicting the log 2 fold change in metabolite concentration between PDAC and LUAD TIF for metabolites measured using stable isotope dilution. A fold change of 1.5 and raw p-value of 0.01 assuming unequal variance were used to select significantly altered metabolites indicated in pink. For all panels, n = 5 for PDAC subcutaneous allograft TIF samples and n = 10 for LUAD subcutaneous allograft TIF samples. 10.7554/eLife.44235.034 Figure 5—source data 1. Concentrations of 104 metabolites determined by both external standard calibration and stable isotope dilution in all subcutaneous PDAC and LUAD TIF samples in .
    Murine Pdac Cancer Cells, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/murine+pdac+cancer+cells/murine+pdac+cells/pmc06510537-213-23-17
    Average 90 stars, based on 1 article reviews
    murine pdac cancer cells - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

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    ( A ) Diagram of experimental models used to test the effect of tumor tissue of origin on TIF metabolite levels. Principal component analysis ( B ) and hierarchical clustering ( C ) of PDAC subcutaneous allograft TIF and LUAD subcutaneous allograft TIF samples based on LC/MS measurements of 104 metabolite concentrations. ( D ) Volcano plot depicting the log 2 fold change in metabolite concentration between PDAC and LUAD TIF for metabolites measured using stable isotope dilution. A fold change of 1.5 and raw p-value of 0.01 assuming unequal variance were used to select significantly altered metabolites indicated in pink. For all panels, n = 5 for PDAC subcutaneous allograft TIF samples and n = 10 for LUAD subcutaneous allograft TIF samples. 10.7554/eLife.44235.034 Figure 5—source data 1. Concentrations of 104 metabolites determined by both external standard calibration and stable isotope dilution in all subcutaneous PDAC and LUAD TIF samples in .

    Journal: eLife

    Article Title: Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

    doi: 10.7554/eLife.44235

    Figure Lengend Snippet: ( A ) Diagram of experimental models used to test the effect of tumor tissue of origin on TIF metabolite levels. Principal component analysis ( B ) and hierarchical clustering ( C ) of PDAC subcutaneous allograft TIF and LUAD subcutaneous allograft TIF samples based on LC/MS measurements of 104 metabolite concentrations. ( D ) Volcano plot depicting the log 2 fold change in metabolite concentration between PDAC and LUAD TIF for metabolites measured using stable isotope dilution. A fold change of 1.5 and raw p-value of 0.01 assuming unequal variance were used to select significantly altered metabolites indicated in pink. For all panels, n = 5 for PDAC subcutaneous allograft TIF samples and n = 10 for LUAD subcutaneous allograft TIF samples. 10.7554/eLife.44235.034 Figure 5—source data 1. Concentrations of 104 metabolites determined by both external standard calibration and stable isotope dilution in all subcutaneous PDAC and LUAD TIF samples in .

    Article Snippet: For subcutaneous xenograft studies, 12 week old C57BL/6J animals purchased from Jackson Laboratories (IMSR Cat# JAX:000664, RRID: IMSR_JAX:000664 ) were injected with 100,000 murine PDAC or LUAD cancer cells (suspended in a volume of 100 μL of Matrigel (Corning, 354234) brought to 10 mg/ml with RPMI-1640 (Corning, 50–020-PC) into the subcutaneous space on the flank of the mice.

    Techniques: Liquid Chromatography with Mass Spectroscopy, Concentration Assay, Isotope Dilution

    ( A ) Diagram of experimental models used to test the effect of tumor tissue of origin on TIF metabolite levels. Principal component analysis ( B ) and hierarchical clustering ( C ) of PDAC subcutaneous allograft TIF and LUAD subcutaneous allograft TIF samples based on LC/MS measurements of 67 metabolites quantified using isotope-labeled internal standards. For all panels, n = 5 for PDAC subcutaneous allograft TIF samples and n = 10 for LUAD subcutaneous allograft TIF samples. 10.7554/eLife.44235.035 Figure 5—figure supplement 1—source data 1. Concentrations of 66 metabolites determined by only stable isotope dilution in all subcutaneous PDAC and LUAD TIF samples in .

    Journal: eLife

    Article Title: Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

    doi: 10.7554/eLife.44235

    Figure Lengend Snippet: ( A ) Diagram of experimental models used to test the effect of tumor tissue of origin on TIF metabolite levels. Principal component analysis ( B ) and hierarchical clustering ( C ) of PDAC subcutaneous allograft TIF and LUAD subcutaneous allograft TIF samples based on LC/MS measurements of 67 metabolites quantified using isotope-labeled internal standards. For all panels, n = 5 for PDAC subcutaneous allograft TIF samples and n = 10 for LUAD subcutaneous allograft TIF samples. 10.7554/eLife.44235.035 Figure 5—figure supplement 1—source data 1. Concentrations of 66 metabolites determined by only stable isotope dilution in all subcutaneous PDAC and LUAD TIF samples in .

    Article Snippet: For subcutaneous xenograft studies, 12 week old C57BL/6J animals purchased from Jackson Laboratories (IMSR Cat# JAX:000664, RRID: IMSR_JAX:000664 ) were injected with 100,000 murine PDAC or LUAD cancer cells (suspended in a volume of 100 μL of Matrigel (Corning, 354234) brought to 10 mg/ml with RPMI-1640 (Corning, 50–020-PC) into the subcutaneous space on the flank of the mice.

    Techniques: Liquid Chromatography with Mass Spectroscopy, Labeling, Isotope Dilution